Embodiments of systems and methods are provided for provisioning a database of trusted users stored locally on one or more information handling systems. The systems and methods disclosed herein may utilize a database of trusted users (otherwise referred to as a trusted multi-user database, or TMU database), a database template and/or policy stored within a remote system (e.g., a cloud or backend server) to remotely manage and provision a TMU database stored locally within one or more information handling systems. In doing so, the systems and methods disclosed herein may be used to securely back-up and restore a TMU database stored locally with an IHS, remotely manage enrollment and provisioning of a TMU database stored locally within one or more information handling systems based on policy, and apply TMU configuration settings globally to the TMU databases stored locally within a plurality of information handling systems.