Disclosed herein is a polyalkylene oxide ester polymer with a weight average molecular weight Mw in the range of from 500 to 50,000 g/mol and a polydispersity PD in the range of from 2 to 6, including 10 to 560 ether groups and 2 to 51 ester groups that are interconnected with alkylene groups, which are significantly more biodegradable than conventional polyalkylene oxide polymers. Further disclosed herein are a method of preparing a polyalkylene oxide ester polymer and a method of using the polyalkylene oxide ester polymer.