Orthosis systems are disclosed, having a wearable assembly and a user replaceable orthosis effector assembly. The wearable assembly includes a motor mechanism and a coupler that is movable by the motor mechanism between a starting location and an unloading location. The coupler has a receiving space. The effector assembly couples to the wearable assembly and has a tension element that actuates the effector assembly. A first end of the tension element is seated in the receiving space of the coupler when the effector assembly is coupled to the wearable assembly. The first end of the tension element is releasable from the receiving space when the coupler is in the unloading location, decoupling the effector assembly from the wearable assembly.