- 专利标题： HETEROARYL DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT
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申请号： US18559542申请日： 2022-04-08
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公开(公告)号： US20240262815A1公开(公告)日： 2024-08-08
- 发明人: Younho LEE , Seonah HWANG , Woomi DO , Inseob SHIM , Hwa LEE , Jungbeom SON , Namdoo KIM , Sunghwan KIM , Hongryul JUNG , Jihye YOO
- 申请人： VORONOI INC.
- 申请人地址： KR Incheon
- 专利权人： VORONOI INC.
- 当前专利权人： VORONOI INC.
- 当前专利权人地址： KR Incheon
- 优先权： KR 20210059327 2021.05.07
- 国际申请： PCT/KR2022/005144 2022.04.08
- 进入国家日期： 2023-11-07
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; A61K31/4439 ; A61K31/506 ; A61K31/519 ; A61K31/53 ; A61K31/5377 ; A61K31/5386 ; A61K31/541 ; A61K31/551 ; A61P35/00 ; C07D413/04 ; C07D417/14 ; C07D471/04 ; C07D471/10 ; C07D487/04 ; C07D487/08 ; C07D487/10 ; C07D491/107 ; C07D498/08
摘要：
The present invention relates to an isoxazolidin-2-yl-substituted heteroaryl derivative and a pharmaceutical composition for cancer prevention or treatment, comprising the compound as an active ingredient. The compound exhibits high inhibitory activity against the wild type or mutants of at least one of ErbB2 and ErbB4 and thus can be useful for treating cancers in which ErbB2 and ErbB4 are expressed.
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