A tube cleaning system and method including a nozzle holder operable to secure nozzles in a nozzle arrangement, the nozzle arrangement corresponding to an arrangement of tubes of a tube bundle, and a nozzle positioning system operable to move the nozzle holder and nozzles secured therein, to cause the nozzles to engage a set of tubes of the tubes of the tube bundle, the nozzles configured to direct cleaning fluid into the set of tubes.