Invention Publication
- Patent Title: Malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
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Application No.: US18612538Application Date: 2024-03-21
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Publication No.: US20240279181A1Publication Date: 2024-08-22
- Inventor: Adrian St. Clair Brown , Peter Lamb , William P. Gallagher
- Applicant: Exelixis, Inc.
- Applicant Address: US CA Alameda
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA Alameda
- The original application number of the division: US14340871 2014.07.25
- Main IPC: C07D215/22
- IPC: C07D215/22 ; C07D215/233
![Malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer](/abs-image/US/2024/08/22/US20240279181A1/abs.jpg.150x150.jpg)
Abstract:
Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclo-propane-1,1-dicarboxamide, including a (L)-malate salt, a (D))-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide; and methods of treating cancer comprising administering at least one malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide.
Public/Granted literature
- US2144068A Means for conveying metallic articles through electroplating or like apparatus Public/Granted day:1939-01-17
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