Systems and methods presented herein facilitate coiled tubing operations, and generally relate to the use of flow modeling to generate flow-related data that cannot be measured in order to take re-al-time decisions and real-time predictions on the outcome of future potential actions to be taken by engineers or artificial intelligence to optimize operation performance together with a general method for parameter inference for any uncertain parameters deemed important when designing cleanout operations. In certain situations, a pre-conditioning method for the determination of a reservoir pressure parameter may be used to reduce the effect of its uncertainty on design fidelity. In addition, in certain situations, a pre-conditioning method for the determination of a reservoir inflow performance parameter may be used to reduce the effect of its uncertainty on design fidelity.