- 专利标题： Inhibition of Diacylglycerol Kinase to Augment Adoptive T cell Transfer
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申请号： US18590493申请日： 2024-02-28
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公开(公告)号： US20240307445A1公开(公告)日： 2024-09-19
- 发明人: Steven M. Albelda , Liang-Chuan Wang , Gary Koretzky , Matthew Riese
- 申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 申请人地址： US PA Philadelphia
- 专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 当前专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 当前专利权人地址： US PA Philadelphia
- 分案原申请号： US17230791 2021.04.14
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; A61K38/00 ; A61K38/45 ; C07K2/00 ; C07K16/30 ; C07K16/40 ; C12N5/0783 ; C12N9/16 ; C12N15/113
摘要：
The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DOK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DOK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
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