- 专利标题： MICROGLIAL PROGENITOR CELLS, METHOD FOR MANUFACTURING MICROGLIA, AND MANUFACTURED MICROGLIAL PROGENITOR CELLS AND MICROGLIA
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申请号： US18575385申请日： 2022-07-06
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公开(公告)号： US20240309322A1公开(公告)日： 2024-09-19
- 发明人: Iki SONN , Hideyuki OKANO , Hirotaka WATANABE , Satoru MORIMOTO
- 申请人： KEIO UNIVERSITY
- 申请人地址： JP Minato-ku, Tokyo
- 专利权人： KEIO UNIVERSITY
- 当前专利权人： KEIO UNIVERSITY
- 当前专利权人地址： JP Minato-ku, Tokyo
- 国际申请： PCT/JP2022/026843 2022.07.06
- 进入国家日期： 2023-12-29
- 主分类号： C12N5/079
- IPC分类号： C12N5/079 ; C12N15/85
摘要：
Provided is a method for producing microglia, including: Step (S1) of inducing differentiation of hemangioblasts to obtain microglial progenitor cells; and Step (S2) of inducing differentiation of the microglial progenitor cells to obtain microglia, in which, in the step of obtaining microglial progenitor cells, expression of PU.1 transcription factor encoded by an exogenous gene is induced, and culture is carried out in the presence of FGF2, SCF, IL-3, IL-6, VEGF, and Wnt inhibitor.
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