Systems and methods for software compatibility prediction and remediation for industrial systems. One system includes an electronic processor configured to receive a software inventory for an industrial system and compatibility data associated with each piece of software included in the software inventory. The electronic processor is also configured to generate, via a compatibility engine, a compatibility mapping based on the software inventory and the compatibility data. The electronic processor is also configured to determine, based on the compatibility mapping, a set of compatibility statuses associated with the industrial system. The electronic processor is also configured to generate a graphical user interface (GUI) for display, the GUI including the software inventory, the set of compatibility statuses, and an interactive graphical representation of the compatibility mapping, and, in response to receiving a user interaction with the GUI, dynamically update the GUI based on the user interaction.