A display substrate includes a display region and a peripheral region surrounding the display region, the peripheral region includes a bonding region and a profiled region, the display region is between the bonding region and the profiled region. The display substrate further includes a plurality of compensation scanning lines and a plurality of data lines, at least one of the compensation scanning lines includes a portion in the profiled region, and at least one of the data lines includes a portion in the display region and a portion in the profiled region. An electrostatic discharge circuit and a loading compensation structure are arranged in the profiled region, at least part of the electrostatic discharge circuit is located between the display region and the loading compensation structure, and the electrostatic discharge circuit is coupled to the plurality of data lines.