Invention Publication
- Patent Title: COMPOUNDS CONTAINING TETRAHYDRONAPHTHYRIDINONE OR TETRAHYDROPYRIDOPYRIMIDINONE SKELETON, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
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Application No.: US18579501Application Date: 2022-07-14
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Publication No.: US20240327408A1Publication Date: 2024-10-03
- Inventor: Haiying SUN , Yibei XIAO , Yuantao FU , Rongliang TAN , Guangjun XIE , Jinxin JIANG , Yinan YUAN
- Applicant: CHINA PHARMACEUTICAL UNIVERSITY
- Applicant Address: CN Jiangsu
- Assignee: CHINA PHARMACEUTICAL UNIVERSITY
- Current Assignee: CHINA PHARMACEUTICAL UNIVERSITY
- Current Assignee Address: CN Jiangsu
- Priority: CN 2110805091.6 2021.07.16 CN 2210814872.6 2022.07.12
- International Application: PCT/CN2022/105579 2022.07.14
- Date entered country: 2024-01-16
- Main IPC: C07D471/14
- IPC: C07D471/14 ; A61K31/4375 ; A61K31/444 ; A61K31/4745 ; A61K31/519 ; A61P35/02 ; C07D471/04 ; C07D491/147 ; C07D495/14 ; C07D513/14
Abstract:
The present invention is related to compounds of formula I containing a tetrahydronaphthyridinone or tetrahydropyridopyrimidinone skeleton and preparation methods therefor. It has been experimentally verified that the compounds containing a tetrahydronaphthyridinone or tetrahydropyridopyrimidinone skeleton have significant agonistic effects on caseinolytic protease P (ClpP), and can be applied in the treatment of various cancers.
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