- 专利标题: SELF-ASSEMBLING PEPTIDE AMPHIPHILES DISPLAYING A TRANSFORMING GROWTH FACTOR BETA 1 (TGF-ß1) MIMETIC EPITOPE
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申请号: US18578613申请日: 2022-07-28
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公开(公告)号: US20240336666A1公开(公告)日: 2024-10-10
- 发明人: Shelby Chi YUAN , Samuel l. STUPP , Nicholas A. SATHER
- 申请人: Northwestern University
- 申请人地址: US IL Evanston
- 专利权人: Northwestern University
- 当前专利权人: Northwestern University
- 当前专利权人地址: US IL Evanston
- 国际申请: PCT/US2022/074263 2022.07.28
- 进入国家日期: 2024-01-11
- 主分类号: C07K14/495
- IPC分类号: C07K14/495 ; A61K9/51 ; A61K38/00 ; A61P21/00
摘要:
Provided herein are self-assembling peptide amphiphiles (PAs) comprising a bioactive Transforming growth factor beta 1 (TGF-β1) mimetic epitope, high-aspect-ratio nanostructures of PAs displaying a TGF-β1 mimetic epitope, and methods of enhancing cartilage regeneration/repair and/or treatment of osteoarthritis and other musculoskeletal injuries and diseases.
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