Invention Publication
- Patent Title: NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
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Application No.: US18616995Application Date: 2024-03-26
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Publication No.: US20240343756A1Publication Date: 2024-10-17
- Inventor: Maria Jesus Blanco-Pillado , Francesco G. SALITURO , Marshall Lee MORNINGSTAR
- Applicant: SAGE THERAPEUTICS, INC.
- Applicant Address: US MA Cambridge
- Assignee: SAGE THERAPEUTICS, INC.
- Current Assignee: SAGE THERAPEUTICS, INC.
- Current Assignee Address: US MA Cambridge
- Main IPC: C07J43/00
- IPC: C07J43/00 ; C07J41/00

Abstract:
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R19, R5, R3a, R1a, R1b, R2a, R2b, R4a, R4b, R6a, R6b, R7a, R7b, R11a, R11b, R12a, R12b, R18, RD, and q are defined herein. L is selected from the group consisting of: wherein A indicates the point of attachment at C17 and wherein X is selected from the group consisting of —C(0)N(R55a)(R55b), —N(R55a)(R55b), —N(R55b)C(O)(R55a), and R55C wherein R55c is carbon-bound substituted or unsubstituted heteroaryl or substituted or unsubstituted aryl. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
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