- 专利标题： THREE-DIMENSIONAL DIRECT NEURONAL REPROGRAMMING TO MODEL ALZHEIMER'S DISEASE IN HUMAN NEURONS
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申请号： US18633066申请日： 2024-04-11
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公开(公告)号： US20240352414A1公开(公告)日： 2024-10-24
- 发明人: Andrew Yoo , Zhao Sun
- 申请人： Washington University
- 申请人地址： US MO St. Louis
- 专利权人： Washington University
- 当前专利权人： Washington University
- 当前专利权人地址： US MO St. Louis
- 主分类号： C12N5/0793
- IPC分类号： C12N5/0793 ; C12N15/113 ; C12N15/86 ; G01N33/50
摘要：
Provided herein are methods of making and using reprogrammed neuronal cells and neuronal spheroids from patient-derived somatic cells in 3D-cultures, by expressing at least one neurogenic miRNA and optionally at least one neurogenic transcription factor.
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