Footwear uppers include a footwear upper base formed from one or more component parts and including: (i) an instep region including at least one of a tongue base region or instep base region and (ii) a heel-containing region. A bladder is engaged with the footwear upper. The bladder includes: (i) at least a first instep chamber engaged with the instep region, (ii) at least a first heel and/or ankle support chamber engaged with the heel-containing region, and (iii) a first fluid line connecting the first instep chamber and the first heel and/or ankle support chamber and placing the first instep chamber in fluid communication with the first heel and/or ankle support chamber. Fluid moving from the first instep chamber to the first heel and/or ankle support chamber (e.g., under force applied by a footwear securing strap) provides further support for the wearer's heel and/or ankle.