A tubing hanger assembly may include a tubing hanger and an annulus plenum designed for annulus flow that allows for communication of otherwise discontinuous bores and/or flow paths above and below the annular plenum. An annulus plenum flow path arrangement is used to connect discontinuous annulus bores from the top and the bottom of the tubing hanger in a way that maximizes flow through area while leaving space in the tubing hanger for other through bores. Further, a specifically designed flange may reduce the size and quantity of fasteners and be used in areas where radial space does not permit a full flange. The flange is compact and designed to maximize the size of an equipment-loaded bore that needs an end connection while doing so in a space-constrained environment.