Systems and methods for infection treatment evaluation is provided. The system receives patient encounter records including patient attribute data and patient LoS data. The system generates, via an LoS estimation model, LoS estimations based on the patient attribute data of each of the patient encounter records. The patient attribute data includes vital sign data, patient demographic data, laboratory data, medical condition data, infection type data, medication administration data, and/or discharge type. The system further generates, via a metric analyzer, evaluation metrics based on the LoS estimations and the patient LoS data of each of the patient encounter records. The system may also include a user interface configured to display at least a portion of the one or more evaluation metrics. The system may also train the LoS estimation model with a historical encounter records. Each of the historical encounter records includes historical attribute data and historical recovery data.