Devices for removing occlusive material from blood lumens and similar physiological structures are provided and generally include a progressive cavity pump. The progressive cavity pump may be integrated into a handle assembly or a distal end of a catheter and may be drive by a motor activated by a controller. In certain implementations, the controller may be configured to activate the motor to generate a pulsatile vacuum using the progressive cavity pump. To facilitate activation of the motor by the controller, the device may further include a pressure sensor configured to measure pressure distal the progressive cavity pump.