Invention Application
- Patent Title: METHODS AND COMPOSITIONS FOR PERTURBING MONOCYTE AND NEUTROPHIL LINEAGES
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Application No.: US18687684Application Date: 2022-09-14
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Publication No.: US20240374592A1Publication Date: 2024-11-14
- Inventor: Morag Helen STEWART , Mauricio CORTES , Fabian Alexander WOLF , Nicholas McCartney PLUGIS
- Applicant: Flagship Pioneering Innovations VI, LLC
- Applicant Address: US MA Cambridge
- Assignee: Flagship Pioneering Innovations VI, LLC
- Current Assignee: Flagship Pioneering Innovations VI, LLC
- Current Assignee Address: US MA Cambridge
- International Application: PCT/US2022/043513 WO 20220914
- Main IPC: A61K31/506
- IPC: A61K31/506 ; A61K31/166 ; A61K31/167 ; A61K31/18 ; A61K31/341 ; A61K31/35 ; A61K31/365 ; A61K31/4184 ; A61K31/496 ; A61K31/513 ; A61K31/519 ; A61K31/535 ; G01N33/50
Abstract:
The present disclosure relates, inter alia, to perturbagens and methods for directing a change or inhibiting a change in the cell state of a hematopoietic progenitor cell. It also relates to methods for increasing or decreasing a quantity of neutrophils, monocytes or immediate progenitors thereof and/or the ratios thereof. Further, the present disclosure relates to methods for treating diseases or disorders characterized by, at least, abnormal ratios of neutrophils to monocytes and/or abnormal numbers thereof.
Information query
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