Invention Application
- Patent Title: CANCER DIAGNOSIS AND CANCER-TYPE PREDICTION METHOD BASED ON CELL-FREE DNA AND IMAGE ANALYSIS TECHNOLOGY
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Application No.: US18564601Application Date: 2022-05-30
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Publication No.: US20240379229A1Publication Date: 2024-11-14
- Inventor: CHANG-SEOK KI , EUN HAE CHO , JUNNAM LEE , JIN MO AHN , SOOK RYUN PARK
- Applicant: GC GENOME CORPORATION , THE ASAN FOUNDATION , UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
- Applicant Address: KR Gyeonggi-do; KR Seoul; KR Ulsan
- Assignee: GC GENOME CORPORATION,THE ASAN FOUNDATION,UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
- Current Assignee: GC GENOME CORPORATION,THE ASAN FOUNDATION,UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
- Current Assignee Address: KR Gyeonggi-do; KR Seoul; KR Ulsan
- Priority: KR10-2021-0068892 20210528
- International Application: PCT/KR2022/007661 WO 20220530
- Main IPC: G16H50/20
- IPC: G16H50/20 ; C12Q1/6806 ; C40B50/06 ; G16B30/10 ; G16B40/20 ; G16H30/40

Abstract:
The present invention relates to a method of diagnosing cancer and predicting cancer type using cell-free nucleic acid fragments and image analysis technology, and more particularly, to a method of diagnosing cancer and predicting cancer type by extracting nucleic acids from a biological sample to obtain sequence information (reads), aligning the obtained reads, generating an image including size and coverage information of nucleic acid fragments based on the aligned reads, and then analyzing values calculated by inputting the image into a trained artificial intelligence model. The method of diagnosing cancer and predicting cancer type using size and coverage information of cell-free nucleic acid fragments according to the present invention advantageously shows high sensitivity and accuracy because it generates vectorized data and performs analysis using an AI algorithm.
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