Invention Application
- Patent Title: BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER
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Application No.: US18687615Application Date: 2022-08-30
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Publication No.: US20240382600A1Publication Date: 2024-11-21
- Inventor: Emilie CHAPEAU , Patrick CHENE , Pascal FURET , Laurence KIEFFER , Rainer MACHAUER , Anne PICARD , Tobias SCHMELZLE , Holger SELLNER , Nicolas SOLDERMANN , Markus VOEGTLE , Markus WARTMANN
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- International Application: PCT/IB2022/058133 WO 20220830
- Main IPC: A61K47/54
- IPC: A61K47/54 ; A61K47/55 ; C07D405/14 ; C07D417/12
Abstract:
The present disclosure relates to a conjugate comprising a YAP/TAZ-TEAD Protein Protein Interaction Inhibitor (PPII) linked to a Ligase Binder via a linker, or a pharmaceutically acceptable salt thereof, as well as methods of using such conjugates.
Information query
