Invention Application
- Patent Title: Protein Tyrosine Phosphatase Degraders and Methods of Use Thereof
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Application No.: US17787828Application Date: 2020-12-18
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Publication No.: US20240383886A1Publication Date: 2024-11-21
- Inventor: Gesine Kerstin Veits , Mark E. Fitzgerald , Alexander W. Hird , James A. Henderson , Harit U. Vora , Ramzi F. Sweis , Michael E. Kort , Christopher G. Nasveschuk , Martin Duplessis
- Applicant: CALICO LIFE SCIENCES LLC , ABBVIE INC.
- Applicant Address: US CA South San Francisco; US IL North Chicago
- Assignee: CALICO LIFE SCIENCES LLC,ABBVIE INC.
- Current Assignee: CALICO LIFE SCIENCES LLC,ABBVIE INC.
- Current Assignee Address: US CA South San Francisco; US IL North Chicago
- International Application: PCT/US2020/066243 WO 20201218
- Main IPC: C07D417/14
- IPC: C07D417/14 ; A61K31/454 ; A61K31/4545 ; A61K31/496 ; C07D471/04
Abstract:
Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer 5 or a metabolic disease.
Information query
