A process for a laser plume interaction for a predictive defect model for multi-laser additive manufacturing of a part including executing computational fluid dynamics modeling of a gas flow in an additive manufacturing machine manufacturing chamber; approximating a laser plume relative to a melt pool on a powder bed disposed on a build plate within the manufacturing chamber; executing a space-time analysis to identify a laser plume interaction; creating a plume interaction zone map; feeding the plume interaction zone map prediction into a multi-laser defect model; and predicting defect location and density to accumulate lack-of-fusion risk as a function of part placement, orientation, and scan strategy.