Embodiments of the present disclosure provide an array substrate and a related display panel and a method of manufacturing thereof. An array substrate comprises: a substrate; a first light-shielding layer; a first dielectric layer which comprises a first opening; a transistor, which comprises an active layer with a first source/drain region, a second source/drain region, and a channel region; a second dielectric layer, which comprises a second opening, wherein a second projection of the second opening on the substrate at least partially overlaps with a first projection of the first opening on the substrate; a first conductive layer; a third dielectric layer, which comprises a third opening, wherein a third projection of the third dielectric layer on the substrate at least partially overlaps with the first projection and the second projection; a fourth dielectric layer, which comprises a fourth opening, wherein a fourth projection of the fourth dielectric layer on the substrate at least partially overlaps with the first projection of the first opening, the second projection of the second opening, and the third projection of the third opening; and a second conductive layer.