Invention Application
- Patent Title: PROPEPTIDE OF LYSYL OXIDASE FOR TREATMENT OF CANCER
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Application No.: US18804150Application Date: 2024-08-14
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Publication No.: US20240398906A1Publication Date: 2024-12-05
- Inventor: Irit SAGI , Nikolaos A. AFRATIS , Inna SOLOMONOV , Carmit LEVY , Shivang PARIKH
- Applicant: Yeda Research and Development Co. Ltd. , Ramot at Tel-Aviv University Ltd.
- Applicant Address: IL Rehovot; IL Tel-Aviv
- Assignee: Yeda Research and Development Co. Ltd.,Ramot at Tel-Aviv University Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.,Ramot at Tel-Aviv University Ltd.
- Current Assignee Address: IL Rehovot; IL Tel-Aviv
- Main IPC: A61K38/44
- IPC: A61K38/44 ; A61K38/17 ; A61K45/06 ; A61P35/00

Abstract:
A method of treating a cancer which is characterized by an up-regulation of expression of lysyl oxidase (LOX) and heat shock protein 70 (HSP70) is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a propeptide of lysyl oxidase (LOX), said polypeptide being devoid of LOX catalytic activity, wherein said polypeptide binds to both LOX and heat shock protein 70 (HSP70) with a EC50 of less than 100 nM.
Public/Granted literature
- US2721953A Electron discharge device Public/Granted day:1955-10-25
Information query
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