A cytology brush includes a shaft including a fluid lumen configured for passage of a fluid; a brush body including: a fixed element; and a moveable element with a radial outward surface and a plurality of bristles, wherein the bristles protrude externally from the radial outward surface. The moveable element is configured to receive the fluid through the fluid lumen to expand from an unexpanded configuration to an expanded configuration and in the unexpanded configuration of the moveable element, the bristles are in a retracted configuration and in the expanded configuration the bristles are in a deployed configuration.