The invention provides a method for treating a tumor excise site defined by a center and edges, and includes simultaneously exposing the tumor site to radiation and pulsating heat. The invention also provides a device for treating tumors at a target site, the including a first balloon containing a radio isotope; a second balloon encasing the first balloon wherein the second balloon comprises structures to create a void between the first balloon and the second balloon; wherein the void is adapted to receive pulsing, temperature treated fluid.