A driving circuit, a driving module, a driving method, a display substrate and a display device are provided. The driving circuit includes a first leakage prevention circuit, an output circuit and a first control node control circuit; the first leakage prevention circuit is configured to control to connect or disconnect the first control node, the first node and the first intermediate node under the control of a first voltage signal provided by the first voltage line according to a potential of the first intermediate node, control to connect or disconnect the first intermediate node and the second voltage line under the control of the potential of the first node, and control to disconnect the first control node and the first node when the first intermediate node and the second voltage line is connected.