BROADLY STATED, THE PRESENT SPERMICIDAL AND GERMICIDAL COMPOSITIONS COMPRISE, IN COMBINATION, THE FOLLOWING INGREDIENTS: (A) 2((2-HYDROXY-5-NONYL-BENZYL)-METHYLAMINO)ETHANE SULFONIC ACID AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF (HEREINAFTER REFERRED TO AS THE UNSUBSTITUTED SULFONIC ACID), (B) $(3 - (DIMETHYL-AMINO-METHYL)-2-HYDROXY-5NONYL-BENZYL)METHYL-AMINO)ETHANE SULFONIC ACID AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF (HEREINAFTER REFERRED TO AS THE SUBSTITUTED SULFONIC ACID), (C) COCO-BENZYL-DIMETHYL AMMONIUM HALIDE, E.G. THE CHLORIDE, BROMIDE AND IODIDE, AND ESPECIALLY THE CHLORIDE. THE ABOVE COMPOSITION HAVE BEEN FOUND TO BE BIOLOGICALLY ACTIVE AGAINST A WIDE RANGE OF ORGANISM INCLUDING LOGICALLY ACTIVE AGAINST A WIDE RANGE OF ORGANISM INCLUDING THE VENERAL TYPE ORGANISMS SUCH AS NEISSERIA GONORRHEAE, TREPONEMA PALLIDUM AND OTHER SPIROCHETES, HEMOPHILUS DUCREYII, FLAGELLATES, SUCH AS TRICHOMONAS VAGINALIS AND RELATED ORGANISMS. THE COMPOSITIONS EXHIBIT UNEXPECTED AND UNUSUAL PROPERTIES OF BEING SPERMICIDAL AND, THEREFORE, ARE PARTICULARLY USEFUL AS A CONTRACEPTIVE WHICH ALSO CONTROLS AND/OR PREVENTS INFECTION WITH VENEREAL DISEASE ORGANISMS, E.G. NEISSERIA GONORRHEA AND TREPONEMA PALLIDUM.