发明授权
- 专利标题： Furfuryl amino-coumarins
- 专利标题（中）： 芳香族氨基酸
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申请号： US3726902D申请日： 1971-07-27
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公开(公告)号： US3726902A公开(公告)日： 1973-04-10
- 发明人: SCHRAVEN E , NITZ R , RESAG K , BEYERLE R , STACHEL I
- 申请人： CASSELLA FARBWERKE MAINKUR AG
- 专利权人： Cassella Farbwerke Mainkur Ag
- 当前专利权人： Cassella Farbwerke Mainkur Ag
- 优先权： DEC0044420 1968-01-19; US16659871 1971-07-27
- 主分类号： C07D311/16
- IPC分类号： C07D311/16 ; C07D7/26
摘要：
THE PRESENT INVENTION RELATES TO NEW COUMARIN COMPOUNDS USEFUL AS CORONARY DILATORS AND HAVING THE FORMULA
2-(O=),3-(R-CH2-CH(-OOC-C6H4-(R3)M)-CH2-),4-R1,(R2)2-2H-
CHROMENE
OR THE HYDROCHLORIC ACID ADDITION SALTS THEREOF, AND TO METHODS OF PREPARING SAME EITHER BY ACYLATING, IN THE PRESENCE OF ACID-BINDING AGENTS, IF DESIRED, COUMARIN DERIVATIVES HAVING THE FORMULA
2-(O=),3-(R''-CH2-CH(-OH)-CH2-),4-R1,(R2)2-2H-CHROMENE
WITH ACYLATING AGENTS SELECTED FROM THE GROUP CONSISTING OF ALKOXYBENZOIC ACID HAVING THE FORMULA
HOOC-C6H4-(R3)M
AND FUNCTIONAL DERIVATIVES THEREOF, OR BY CONDENSING, IN THE PRESENCE OF ACID-BINDING AGENTS, IF DESIRED, COUMARIN DERIVATIVES HAVING THE FORMULA
2-(O=),3-(R4-CH2-CH(-OOC-C6H4-(R3)M)-CH2-),4-R1,(R2)2-
2H-CHROMENE
WITH AN AMINE HAVING THE FORMULA RH, WHEREIN R IS SELECTED FROM SECONDARY FURFURYLAMINO AND SECONDARY TETRAHYDROFURFURLAMINO, WHICH IS BOUND VIA THE NITROGEN ATOM, R1 IS SELECTED FROM THE GROUP CONSISTING OF ALKYL RADICALS HAVING 1-4 CARBON ATOMS AND PHENYL, R2 IS SELECTED FROM THE GROUP CONSISTING OF 5,6-, 6,7-, AND 7,8POSITIONED ALKOXY GROUPS HAVING 1-4 CARBON ATOMS, R3 IS SELECTED FROM ALKOXY GROUPS HAVING 1-4 CARBON ATOMS, R4 IS SELECTED FROM THE GROUP CONSISTING OF CHLORINE AND BROMINE, R'' IS SELECTED FROM THE GROUP CONSISTING OF SECONDARY FURFURLAMINO AND SECONDARY TETRAHYDROFURFURYLAMINO, AND M IS SELECTED FROM THE GROUP CONSISTING OF 1, 2, AND 3.
2-(O=),3-(R-CH2-CH(-OOC-C6H4-(R3)M)-CH2-),4-R1,(R2)2-2H-
CHROMENE
OR THE HYDROCHLORIC ACID ADDITION SALTS THEREOF, AND TO METHODS OF PREPARING SAME EITHER BY ACYLATING, IN THE PRESENCE OF ACID-BINDING AGENTS, IF DESIRED, COUMARIN DERIVATIVES HAVING THE FORMULA
2-(O=),3-(R''-CH2-CH(-OH)-CH2-),4-R1,(R2)2-2H-CHROMENE
WITH ACYLATING AGENTS SELECTED FROM THE GROUP CONSISTING OF ALKOXYBENZOIC ACID HAVING THE FORMULA
HOOC-C6H4-(R3)M
AND FUNCTIONAL DERIVATIVES THEREOF, OR BY CONDENSING, IN THE PRESENCE OF ACID-BINDING AGENTS, IF DESIRED, COUMARIN DERIVATIVES HAVING THE FORMULA
2-(O=),3-(R4-CH2-CH(-OOC-C6H4-(R3)M)-CH2-),4-R1,(R2)2-
2H-CHROMENE
WITH AN AMINE HAVING THE FORMULA RH, WHEREIN R IS SELECTED FROM SECONDARY FURFURYLAMINO AND SECONDARY TETRAHYDROFURFURLAMINO, WHICH IS BOUND VIA THE NITROGEN ATOM, R1 IS SELECTED FROM THE GROUP CONSISTING OF ALKYL RADICALS HAVING 1-4 CARBON ATOMS AND PHENYL, R2 IS SELECTED FROM THE GROUP CONSISTING OF 5,6-, 6,7-, AND 7,8POSITIONED ALKOXY GROUPS HAVING 1-4 CARBON ATOMS, R3 IS SELECTED FROM ALKOXY GROUPS HAVING 1-4 CARBON ATOMS, R4 IS SELECTED FROM THE GROUP CONSISTING OF CHLORINE AND BROMINE, R'' IS SELECTED FROM THE GROUP CONSISTING OF SECONDARY FURFURLAMINO AND SECONDARY TETRAHYDROFURFURYLAMINO, AND M IS SELECTED FROM THE GROUP CONSISTING OF 1, 2, AND 3.
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