An inverted type syringe in which a double-ended needle is molded into a solid post with a socket at its upper end complementary to a stopper piston closing a cylindrical vial. In use, as the stopper is inserted into the socket it is punctured by the needle so that a continued pressure on the vial causes ejection of the contents. In a preferred form, a cylindrical plastic holder telescopically receives the vial and a hub on the holder is cemented or sealed to the post.