发明授权
- 专利标题: Process for producing citric acid isocitric acid and microbial cells by fermentation
- 专利标题(中): 通过发酵生产柠檬酸酸和微生物细胞的方法
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申请号: US3773620D申请日: 1970-09-24
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公开(公告)号: US3773620A公开(公告)日: 1973-11-20
- 发明人: KIMURA K , NAKANISHI T
- 申请人: KYOWA HAKKO KOGYO KK
- 专利权人: Kyowa Hakko Kogyo Kk
- 当前专利权人: Kyowa Hakko Kogyo Kk
- 优先权: JP8033369 1969-10-09; JP9292569 1969-11-21
- 主分类号: C12P7/48
- IPC分类号: C12P7/48 ; C12B1/00
摘要:
Processes for producing citric acid together with microbial cells as well as producing increased yields of citric acid and/or isocitric acid by fermentation are described. Hydrocarbonassimilating microorganisms are employed in media containing hydrocarbons as the main carbon source. The addition of alcohols, such as C1-C20 saturated alcohols, to the medium permits the accumulation of citric acid together with the obtained microbial cells. The addition of ferrocyanides, such as potassium or sodium ferrocyanide, to the medium enhances the yield of isocitric acid, while the addition of monofluoroacetic acid or a salt thereof to the medium enhances the yield of citric acid.