发明授权
- 专利标题： Production of optically active antipodes
- 专利标题（中）： 生产光学活性抗体
-
申请号： US3790445D申请日： 1970-11-20
-
公开(公告)号： US3790445A公开(公告)日： 1974-02-05
- 发明人: GIBIAN H , KIESLICH K , WALSH R , RUFER C , SCHRODER E , KOCH H , KOSMOL H
- 申请人： SCHERING AG
- 专利权人： Bayer Schering Pharma AG
- 当前专利权人： Bayer Schering Pharma AG
- 优先权： DESC037715 1965-09-14
- 主分类号： C12P7/26
- IPC分类号： C12P7/26 ; A61K31/565 ; A61K31/566 ; C07B57/00 ; C07C49/613 ; C07C59/82 ; C07C62/32 ; C07D317/50 ; C07D317/54 ; C07J1/00 ; C07J15/00 ; C12D13/00
摘要：
IN A PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS, SUCH AS INTERMEDIATES FOR THE PRODUCTION OF STEROID HORMONES IN WHICH AN OPTICALLY INACTIVE COMPOUND OF THE FORMULA
Y-CI(-CH3)(-Z)2
WHEREIN C1 IS A SYMMETRIC CARBON ATOM AND THE TWO Z GROUPS ARE IDENTICAL ALIPHATIC GROUPS JOINED TOGETHER, EACH OF WHICH BEARS A KETO GROUP, AND Y IS THE REMAINDER OF THE MOLECULE, IS SUBJECTED TO A MICROBIOLOGICAL ENZYME SYSTEM TO PRODUCE AN OPTICALLY ACTIVE ANTIPODE OF THE FORMULA
Y-CA(-CH3)(-Z)-Z''
WHEREIN Y AND Z HAVE THE VALUES GIVEN ABOVE, CA IS THE ASYMMETRICAL CARBON ATOM CORRESPONDING TO C1 AND Z'' IS A LIGAND OTHERWISE CORRESPONDING TO Z BEARING A HYDROXY RATHER THAN A KETO GROUP, THE IMPROVEMENT WHICH COMPRISES EMPLOYING A MICROORGANISM SELECTED FROM THE GROUP CONSISTING OF ASPERGILLIUS OCHRACCEUS, BACILLUS ESTERFICANS, BACILLUS THURINGIENSIS AND SACCHAROMYCES UVARUM.
Y-CI(-CH3)(-Z)2
WHEREIN C1 IS A SYMMETRIC CARBON ATOM AND THE TWO Z GROUPS ARE IDENTICAL ALIPHATIC GROUPS JOINED TOGETHER, EACH OF WHICH BEARS A KETO GROUP, AND Y IS THE REMAINDER OF THE MOLECULE, IS SUBJECTED TO A MICROBIOLOGICAL ENZYME SYSTEM TO PRODUCE AN OPTICALLY ACTIVE ANTIPODE OF THE FORMULA
Y-CA(-CH3)(-Z)-Z''
WHEREIN Y AND Z HAVE THE VALUES GIVEN ABOVE, CA IS THE ASYMMETRICAL CARBON ATOM CORRESPONDING TO C1 AND Z'' IS A LIGAND OTHERWISE CORRESPONDING TO Z BEARING A HYDROXY RATHER THAN A KETO GROUP, THE IMPROVEMENT WHICH COMPRISES EMPLOYING A MICROORGANISM SELECTED FROM THE GROUP CONSISTING OF ASPERGILLIUS OCHRACCEUS, BACILLUS ESTERFICANS, BACILLUS THURINGIENSIS AND SACCHAROMYCES UVARUM.
信息查询
