发明授权
US3823164A 5,6,7,8-tetrahydro-2,5(and 4,5)-dioxo-1-benzopyrans
失效
5,6,7,8-四氢呋喃-2,5（和4,5） - 二氧代-1-苯并噻吩
- 专利标题： 5,6,7,8-tetrahydro-2,5(and 4,5)-dioxo-1-benzopyrans
- 专利标题（中）： 5,6,7,8-四氢呋喃-2,5（和4,5） - 二氧代-1-苯并噻吩
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申请号： US31524772申请日： 1972-12-14
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公开(公告)号： US3823164A公开(公告)日： 1974-07-09
- 发明人: SELLSTEDT J , BELL S , MC CAULLY R
- 申请人： AMERICAN HOME PROD
- 专利权人： American Home Prod
- 当前专利权人： American Home Prod
- 优先权： US31524772 1972-12-14; US17540971 1971-08-26
- 主分类号： C07D311/08
- IPC分类号： C07D311/08 ; C07D7/26
摘要：
COMPOUNDS OF THE FORMULA:
2,3-(-X-O-),R,R2-CYCLOHEX-2-EN-1-ONE
IN WHICH X IS THE MOIETY
-CO-C(-R3)=C(-CO-Z)-
Z IS A MEMBER SELECTED FOR THE GROUP CONSISTING OF
-OR4, -N(-R5)-R6
-CL,-BR, AND -OM; R, R2, R3, AND R5 ARE INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF -H, LOWER ALKYL, PHENYL AND BENZYL, R6 IS SELECTED FROM THE GEOUP CONSISTING OF -H, LOWER ALKYL, PHEMYL, BENZYL, LOWER DIALKYLAMINOALKYL AND CYCLOALKYL OF 3 TO 10 CARBON ATOMS, AND WHEN TAKEN WITH R5 AND THE NITROGEN ATOM TO WHICH THEY ARE BONDED FORMS THE MORPHOLINO, PIPERIDINO AND PIPERAZINO GROUPS, AND M IS SELECTED FROM ALKALI METAL CATION AND -NH4, ARE IMMUNO-INFLAMMATORY AGENTS POSSESSING ANTIALLERGIC AND ANTIINFLAMMATORY ACTIVITY. THE COMPOUNDS OF THSI INVENTION ARE ALSO INTERMEDIATES FOR THE SYNTHESIS OF KNOWN CHROMONE AND COUMARIN DERIVATIVES.
2,3-(-X-O-),R,R2-CYCLOHEX-2-EN-1-ONE
IN WHICH X IS THE MOIETY
-CO-C(-R3)=C(-CO-Z)-
Z IS A MEMBER SELECTED FOR THE GROUP CONSISTING OF
-OR4, -N(-R5)-R6
-CL,-BR, AND -OM; R, R2, R3, AND R5 ARE INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF -H, LOWER ALKYL, PHENYL AND BENZYL, R6 IS SELECTED FROM THE GEOUP CONSISTING OF -H, LOWER ALKYL, PHEMYL, BENZYL, LOWER DIALKYLAMINOALKYL AND CYCLOALKYL OF 3 TO 10 CARBON ATOMS, AND WHEN TAKEN WITH R5 AND THE NITROGEN ATOM TO WHICH THEY ARE BONDED FORMS THE MORPHOLINO, PIPERIDINO AND PIPERAZINO GROUPS, AND M IS SELECTED FROM ALKALI METAL CATION AND -NH4, ARE IMMUNO-INFLAMMATORY AGENTS POSSESSING ANTIALLERGIC AND ANTIINFLAMMATORY ACTIVITY. THE COMPOUNDS OF THSI INVENTION ARE ALSO INTERMEDIATES FOR THE SYNTHESIS OF KNOWN CHROMONE AND COUMARIN DERIVATIVES.
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