发明授权
US3872082A Substituted purineribofuranoside-3,5-cyclophosphate compounds and process for their preparation
失效
取代的嘌呤呋喃糖苷-3,5-环磷酸酯化合物及其制备方法
- 专利标题： Substituted purineribofuranoside-3,5-cyclophosphate compounds and process for their preparation
- 专利标题（中）： 取代的嘌呤呋喃糖苷-3,5-环磷酸酯化合物及其制备方法
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申请号： US25239372申请日： 1972-05-11
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公开(公告)号： US3872082A公开(公告)日： 1975-03-18
- 发明人: BERGMEYER HANS ULRICH , NELBOECK-HOCHSTETTER MICHAEL , MICHAL GERHARD , MUHLEGGER KLAUS , WEIMANN GUNTER , ROESCH EGON
- 申请人： BOEHRINGER MANNHEIM GMBH
- 专利权人： Boehringer Mannheim Gmbh
- 当前专利权人： Boehringer Mannheim Gmbh
- 优先权： DE2125077 1971-05-19
- 主分类号： C07H19/213
- IPC分类号： C07H19/213 ; A61K31/70 ; A61K31/7042 ; A61K31/7052 ; A61K31/7076 ; A61K31/708 ; A61P3/00 ; A61P11/08 ; A61P35/00 ; A61P37/06 ; C07H19/20 ; C07D51/52 ; C07D51/54
摘要：
Novel substituted cyclophosphate compounds of the formula:
WHEREIN X is halogen, hydrocarbyl, sulfhydryl, thioether, alkylsulfoxy, alkylsulfonyl or hydrocarbyl-substituted amino wherein said hydrocarbyl and alkyl radicals contain up to about 12 carbon atoms, and R3 is hydrogen or hydroxyl; ARE PREPARED BY REACTING THE CORRESPONDING AMINE COMPOUND (WHEREIN X in the formula is NH2) with a nitrite and haloboric acid at a temperature below 0*C. to yield a compound wherein X in the formula is halogen, and converting the halogen compound, if desired, to one in which X has the other definitions set forth above, in conventional manner. Alternatively, the novel compounds are prepared from open-ring diamine compounds by reacting with an alkali metal xanthogenate or an orthoformate.
WHEREIN X is halogen, hydrocarbyl, sulfhydryl, thioether, alkylsulfoxy, alkylsulfonyl or hydrocarbyl-substituted amino wherein said hydrocarbyl and alkyl radicals contain up to about 12 carbon atoms, and R3 is hydrogen or hydroxyl; ARE PREPARED BY REACTING THE CORRESPONDING AMINE COMPOUND (WHEREIN X in the formula is NH2) with a nitrite and haloboric acid at a temperature below 0*C. to yield a compound wherein X in the formula is halogen, and converting the halogen compound, if desired, to one in which X has the other definitions set forth above, in conventional manner. Alternatively, the novel compounds are prepared from open-ring diamine compounds by reacting with an alkali metal xanthogenate or an orthoformate.