发明授权
- 专利标题: N-substituted guanidino acid derivatives
- 专利标题(中): N-取代胍基酸衍生物
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申请号: US192557申请日: 1971-10-26
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公开(公告)号: US3935266A公开(公告)日: 1976-01-27
- 发明人: Sadao Hashimoto , Ryuji Sakakibara , Yasushi Kurashige , Katsuo Takikawa , Yoko Osame , Hiroshi Minami , Takashi Suzue
- 申请人: Sadao Hashimoto , Ryuji Sakakibara , Yasushi Kurashige , Katsuo Takikawa , Yoko Osame , Hiroshi Minami , Takashi Suzue
- 申请人地址: JA Tokyo
- 专利权人: Taiho Pharmaceutical Company, Limited
- 当前专利权人: Taiho Pharmaceutical Company, Limited
- 当前专利权人地址: JA Tokyo
- 优先权: JA45-95341 19701028
- 主分类号: A61K31/16
- IPC分类号: A61K31/16 ; A61K31/165 ; C07C67/00 ; C07C239/00 ; C07C279/14 ; C07C103/30
摘要:
An N-substituted guanidino acid derivatives having the following formula of ##EQU1## wherein R is an alkyl having 6 to 15 carbon atoms,. a cycloalkyl having 6 to 15 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.9); A represents R.sup.1 or R.sub.2 CO--, R.sup.1 being an alkyl having 1 to 4 carbon atoms, an alkenyl having 2 to 4 carbon atoms, cyclohexyl, a phenyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, or a benzyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, and R.sup.2 being an alkyl of 1 to 3 carbon atoms, an alkenyl of 2 to 3 carbon atoms, an aryl of 6 to 8 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.2); and n is an integer of 4 to 10. The present compounds are excellent in pharmacological activities, particularly in antagonism to bradykinin and histamine, and useful as anti-inflammatory agent.
公开/授权文献
- US5441491A Method and composition for treating biopsy wounds 公开/授权日:1995-08-15