发明授权
- 专利标题: 1-N-isoserylkanamycins and the production thereof
- 专利标题(中): 1-N-异辛基卡那霉素及其制备
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申请号: US466053申请日: 1974-05-01
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公开(公告)号: US3939143A公开(公告)日: 1976-02-17
- 发明人: Hamao Umezawa , Kenji Maeda , Shinichi Kondo , Sumio Umezawa
- 申请人: Hamao Umezawa , Kenji Maeda , Shinichi Kondo , Sumio Umezawa
- 申请人地址: JA Tokyo
- 专利权人: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
- 当前专利权人: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
- 当前专利权人地址: JA Tokyo
- 优先权: JA48-53151 19730515; JA48-96176 19730829
- 主分类号: C07H15/236
- IPC分类号: C07H15/236 ; C07H15/22
摘要:
1-N-isoseryl derivatives of kanamycin A, kanamycin B and 3',4'-dideoxykanamycin B are now synthesized, which are new and useful compounds active against gram-negative and gram-positive bacteria and also against drug-resistant strains of these bacteria. The production of the 1-N-isoserylkanamycins is made by reacting isoserine with the 1-N-amino group of kanamycin with the functional amino group(s) being protected, following by removal of the amino-protecting groups and by chromatographic separation of the desired 1-N-isoserylation product.
公开/授权文献
- US4509965A Water-steam separator 公开/授权日:1985-04-09