An improved flight control system for use in guided missiles having a plurality of individually actuable control surfaces is shown. In order to overcome the deleterious effects of aerodynamic cross-coupling between control surfaces at a high angle of attack, the disclosed system includes means for first determining the lift force and roll moment of each control surface, and then, in accordance with the determined values of such forces and moments, controlling separately the total pitch lift force, yaw lift force and roll moment generated by all control surfaces. Any desired maneuver, either in pitch or yaw (or both), may therefore be executed without causing any unwanted motion of the missile, such as motion in an undesired plane or rolling of the missile.