发明授权
US3951991A 4-Aryl-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester
失效
4-芳基-6-氨基-3,4-二氢吡啶-2-酮-3,5-二羧酸酯
- 专利标题: 4-Aryl-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester
- 专利标题(中): 4-芳基-6-氨基-3,4-二氢吡啶-2-酮-3,5-二羧酸酯
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申请号: US531599申请日: 1974-12-11
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公开(公告)号: US3951991A公开(公告)日: 1976-04-20
- 发明人: Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
- 申请人: Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
- 申请人地址: DT
- 专利权人: Bayer Aktiengesellschaft
- 当前专利权人: Bayer Aktiengesellschaft
- 当前专利权人地址: DT
- 优先权: DT2242787 19720831
- 主分类号: A61K31/455
- IPC分类号: A61K31/455 ; C07D401/04 ; C07D409/04 ; C07D213/71
摘要:
3,4-Dihydropyridones of the formula ##SPC1##Wherein R.sup.1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; R.sup.2 is a straight, branched or cyclic, saturated or unsaturated hydrocarbon, aryl unsubstituted or substituted by 1 to 3 of the same or different substitutents selected from the group consisting of alkyl, alkoxy, halogen, nitro, cyano, trifluoromethyl, carbalkoxy and SO.sub.n --alkyl wherein n is 0, 1 or 2, or naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, thenyl, furyl or pyrryl unsubstituted or substituted by 1 or more substituents selected from the group consisting of alkyl, alkoxy and halogen; and R.sup.3 is a straight or branched chain hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms, are produced by reacting an .alpha.,.beta.-unsaturated carboxylic acid ester of the formula ##EQU1## wherein R is alkyl, alkenyl or alkynyl, and R.sup.1 and R.sup.2 are as above defined, with an amidine of the formula ##EQU2## wherein R.sup.3 is as above defined. These compounds are useful as coronary agents and as anti-hypertensive agents.
公开/授权文献
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