发明授权
- 专利标题： Phenoxy carboxylic acid derivatives as anti-atheroslerosis agents
- 专利标题（中）： 苯氧基羧酸衍生物作为抗动脉粥样硬化剂
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申请号： US459861申请日： 1974-04-10
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公开(公告)号： US3959484A公开(公告)日： 1976-05-25
- 发明人: Yasushi Nakamura , Kunio Agatsuma , Yoshihiro Tanaka , Shunji Aono
- 申请人： Yasushi Nakamura , Kunio Agatsuma , Yoshihiro Tanaka , Shunji Aono
- 申请人地址： JA Osaka
- 专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人地址： JA Osaka
- 优先权： JA44-29905 19690416; JA44-29907 19690416; JA44-34166 19690502; JA44-34167 19690502; JA44-80041 19691003; JA44-80042 19691003; JA45-102809 19691219; JA45-104194 19691223
- 主分类号： C07C51/367
- IPC分类号： C07C51/367 ; C07C51/41 ; C07C59/68 ; C07C59/72 ; A61K31/235
摘要：
Novel anti-atheroscelersosis agents having the formula, ##SPC1##Wherein typical examples of R.sup.1 and R.sup.2 are hydrogen, C.sub.1 -C.sub.8 alkyl, phenyl, benzyl and phenethyl, or R.sup.1 and R.sup.2 may form cycloalkylidene together with a carbon atom bonded therewith; R.sup.3 and R.sup.4 each is hydrogen or C.sub.1 -C.sub.4 alkyl; Y is hydroxyl, C.sub.1 -C.sub.4 alkoxy, phenoxy or an amine residue; A is hydrogen or a group of the formula, ##EQU1## wherein R.sup.3, R.sup.4 and Y have the same meanings as defined above; and D and E each is hydrogen or halogen.These compounds are produced, for example, by reacting a bisphenolic compound of the formula, ##SPC2## with chloroform and a ketone compound of the formula,R.sup.3 --CO--R.sup.4in the presence of an alkali. Alternatively, they are produced by reacting the bisphenolic compound with .alpha.-halogeno- or .alpha.-hydroxycarboxylic acid derivative of the formula, ##EQU2## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, d, e and T have the same meanings as definend above; and X is halogen or hydroxyl.
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