发明授权
- 专利标题： Aryl ketones and production thereof
- 专利标题（中）： 芳基酮及其制备
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申请号： US600119申请日： 1975-07-29
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公开(公告)号： US4012515A公开(公告)日： 1977-03-15
- 发明人: Junki Katsube , Masaru Nakao , Kikuo Sasajima , Isamu Maruyama , Masaharu Takayama , Keiichi Ono , Shigenari Katayama , Yoshihiro Tanaka , Shigeho Inaba , Hisao Yamamoto
- 申请人： Junki Katsube , Masaru Nakao , Kikuo Sasajima , Isamu Maruyama , Masaharu Takayama , Keiichi Ono , Shigenari Katayama , Yoshihiro Tanaka , Shigeho Inaba , Hisao Yamamoto
- 申请人地址： JA
- 专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人地址： JA
- 主分类号： C07D211/52
- IPC分类号： C07D211/52 ; C07D295/084 ; C07D295/108
摘要：
Novel olefinic aryl ketone compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1.sub.-4 alkyl, or C.sub.1.sub.-4 alkoxy, R.sup.2 is hydrogen or halogen, and R.sup.3 and R.sup.4 are each hydrogen, halogen, C.sub.1.sub.-4 alkyl or trifluoromethyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reaction of an acetylenic alcohol of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above, with formaldehyde and an amine of the formula: ##STR3## wherein R.sup.3 and R.sup.4 are each as defined above; reduction of the resultant acetylenic aryl alcohol; and oxidation of the resultant olefinic aryl alcohol.
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