发明授权
US4017507A 2,3-Dihydro-7-chlorothiazolo[3,2-a]benzimidazole and salt
失效
2,3-二氢-7-氯噻唑并[8 3,2-a {9苯并咪唑和盐
- 专利标题: 2,3-Dihydro-7-chlorothiazolo[3,2-a]benzimidazole and salt
- 专利标题(中): 2,3-二氢-7-氯噻唑并[8 3,2-a {9苯并咪唑和盐
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申请号: US637978申请日: 1975-12-05
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公开(公告)号: US4017507A公开(公告)日: 1977-04-12
- 发明人: Kalman Hideg , Olga Hankovszky , Eva Palosi , Gyorgy Hajos , Laszlo Szporny
- 申请人: Kalman Hideg , Olga Hankovszky , Eva Palosi , Gyorgy Hajos , Laszlo Szporny
- 申请人地址: HU Budapest
- 专利权人: Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人: Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人地址: HU Budapest
- 优先权: HURI509 19730620
- 主分类号: C07D513/04
- IPC分类号: C07D513/04
摘要:
New tricyclic fused imidazole derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for hydrogen or hydroxy,n is equal to zero or one,m is equal to zero, one or two,A stands for a group of the general formula (II), ##STR2## wherein R.sub.2 represents hydrogen or hydroxy,R.sub.3 represents hydrogen or amino, orQ and Z each stand for nitrogen or a=C-- group, orA stands for a group of the general formula (III), ##STR3## wherein R.sub.4 and R.sub.5 each represent hydrogen, methyl, chlorine or nitro,Were prepared by reacting a compound of the general formula (IV) ##STR4## wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), ##STR5## wherein X stands for halogen, R.sub.6 stands for hydrogen and R.sub.7 stands for a group of the general formula (VI),--(ch.sub.2).sub.m --X VI.in which m and X each have the same meanings as defined above, or R.sub.6 and R.sub.7 together stand for oxygen. The reaction is carried out optionally in the presence of a base. The compounds of the general formula (I) can be converted into their acid addition salts.The compounds of the general formula (I) as well as their acid addition salts exert antipyretic and antiphlogistic activities, inhibit the reproduction of viruses, and exert a protecting effect against albumine shock.
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