发明授权
US4021558A 1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines
and salts thereof useful as hypotensive agents
失效
1,3-二氧代-2- {8-（甲氧基苯乙基 - 氨基） - 烷基{9-4,4-二甲基 - 异喹啉及其盐作为降压剂
- 专利标题： 1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents
- 专利标题（中）： 1,3-二氧代-2- {8-（甲氧基苯乙基 - 氨基） - 烷基{9-4,4-二甲基 - 异喹啉及其盐作为降压剂
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申请号： US651568申请日： 1976-01-22
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公开(公告)号： US4021558A公开(公告)日： 1977-05-03
- 发明人: Eberhard Kutter , Volkard Austel , Wolfgang Eberlein , Joachim Heider
- 申请人： Eberhard Kutter , Volkard Austel , Wolfgang Eberlein , Joachim Heider
- 申请人地址： DT Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim GmbH
- 当前专利权人： Boehringer Ingelheim GmbH
- 当前专利权人地址： DT Ingelheim am Rhein
- 优先权： DT2345422 19730908; DT2345423 19730908
- 主分类号： C07D217/24
- IPC分类号： C07D217/24 ; A61K31/47
摘要：
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen, methoxy or methylthio, R.sub.2 is hydrogen or methoxy,n is 2 or 3,R.sub.3 is hydrogen or methyl, andR.sub.4 and R.sub.5, which may be identical to or different from each other, are each hydrogen or methoxy, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, sedatives, antiarrhythmics and bradycardiacs.
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