发明授权
- 专利标题: Diphenoxyacetic acid derivatives
- 专利标题(中): 二苯氧基乙酸衍生物
-
申请号: US531475申请日: 1974-12-11
-
公开(公告)号: US4051170A公开(公告)日: 1977-09-27
- 发明人: Erich Schacht , Werner Mehrhof , Zdenek Simane , Detlev Kayser , Herbert Nowak
- 申请人: Erich Schacht , Werner Mehrhof , Zdenek Simane , Detlev Kayser , Herbert Nowak
- 申请人地址: DT Darmstadt
- 专利权人: Merck Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人: Merck Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人地址: DT Darmstadt
- 优先权: DT2362416 19731215
- 主分类号: C07D295/08
- IPC分类号: C07D295/08 ; C07C51/00 ; C07C51/08 ; C07C59/125 ; C07C59/68 ; C07C59/70 ; C07C67/00 ; C07C69/712 ; C07D215/06 ; C07D215/14 ; C07D215/22 ; C07D215/233 ; C07D295/096 ; C07D311/58 ; C07D335/06
摘要:
Diphenoxyacetic acid derivatives of the general formula ##STR1## wherein R.sub.1 is H or alkyl of 1-4 carbon atoms, R.sub.2 is H or Cl, R.sub.2 is H or Cl, R.sub.3 is piperidino, 4-piperidinophenyl, 1,2,3,4-tetrahydroquinolino, 1-R.sub.4 -1,2,3,4-tetrahydro-4-quinolyl, 4-oxo-1,2,3,4-tetrahydroquinolino, 4-chromanyl, 4-thiochromanyl or 4-chlorophenoxy, and R.sub.4 is H or alkyl of 1-4 carbon atoms, and the physiologically acceptable salts thereof, possess cholesterol level lowering activity and can be prepared by reacting a phenol of the formula ##STR2## with a compound of the formula ##STR3## wherein X is OH, esterified OH, Cl, Br or I, one R is R.sub.2 and the other is R.sub.3 ; or by cyclizing a compound of the formula ##STR4## wherein X.sub.1 is Cl, Br, I, NH.sub.2 OH or an esterified or etherified OH-group and n is 0 or 1; or by treating a compound of the formula ##STR5## wherein Z is a functionally modified carboxyl group different from COOR.sub.1, with a solvolyzing agent, R.sub.1, R.sub.2 and R.sub.3 in each instance having the values given above.
公开/授权文献
- US4988561A Paper coated with synthetic alkali metal aluminosilicates 公开/授权日:1991-01-29