发明授权
- 专利标题: Biphenylyl ethers and method of use
- 专利标题(中): 联苯醚和使用方法
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申请号: US518811申请日: 1974-10-29
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公开(公告)号: US4060609A公开(公告)日: 1977-11-29
- 发明人: Erich Schacht , Werner Mehrhof , Rochus Jonas , Herbert Nowak , Zdenek Simane
- 申请人: Erich Schacht , Werner Mehrhof , Rochus Jonas , Herbert Nowak , Zdenek Simane
- 申请人地址: DT Darmstadt
- 专利权人: Merch Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人: Merch Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人地址: DT Darmstadt
- 优先权: DT2354444 19731031
- 主分类号: C07D295/08
- IPC分类号: C07D295/08 ; C07C217/32 ; C07D211/22 ; C07D211/42 ; C07D223/08 ; C07D295/092 ; A61K31/535
摘要:
Biphenylyl ethers of the formula R--O--CH.sub.2 --CR.sub.1 (OH)--CH.sub.2 Z wherein R.sub.1 is H or CH.sub.3 ; Z is dialkylamino of 2-8 carbon atoms, morpholino, pyrrolidino, piperidino, homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino; R is either biphenylyl substituted by at least one of F, Cl, Br, I, CF.sub.3, NO.sub.2 and piperidino or, when R.sub.1 is CH.sub.3 or when Z is homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino, unsubstituted biphenyl, and the physiologically acceptable acid addition salts thereof, possess cholesterol blood-level-lowering activity and can be produced by reacting a compound of the formula R--O--CH.sub.2 --Y wherein Y is ##STR1## or --CR.sub.1 (OH)--CH.sub.2 X, X being Cl, Br, I or a free or functionally modified OH-group, with an amine of the formula H-Z.
公开/授权文献
- US5660864A Apparatus for introducing injection material into a mold 公开/授权日:1997-08-26
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