发明授权
- 专利标题： Chemical process for preparing .DELTA.9(11) dehydrosteroids
- 专利标题（中）： 制备{66 9（11）脱氢甾醇的化学方法
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申请号： US688714申请日： 1976-05-21
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公开(公告)号： US4064148A公开(公告)日： 1977-12-20
- 发明人: Derek H. R. Barton , Robert H. Hesse
- 申请人： Derek H. R. Barton , Robert H. Hesse
- 申请人地址： MA Cambridge
- 专利权人： Research Institute for Medicine and Chemistry Inc.
- 当前专利权人： Research Institute for Medicine and Chemistry Inc.
- 当前专利权人地址： MA Cambridge
- 优先权： UK22324/75 19750522
- 主分类号： C07J7/00
- IPC分类号： C07J7/00 ; C07J5/00 ; C07J41/00 ; C07J3/00
摘要：
The Specification describes a synthetic route for the preparation of a 9,11-dehydro-3-oxygenated 17.alpha.-hydroxy-20-ketopregnane which comprises the steps (i) electrophilically fluorinating a saturated 9,11-unsubstituted 3-oxygenated-17.alpha.-(esterified hydroxy)-20-ketopregnane, (ii) dehydrofluorinating the resulting 9.alpha.-fluorosteroid, if desired after transformations elsewhere in the molecule have been effected, and (iii) cleaving the ester group at the 17.alpha.-position to generate a 17.alpha.-hydroxy group.
公开/授权文献
- US6075362A Dual contrast fast spin echo with alternating phase-encode 公开/授权日：2000-06-13