发明授权
US4107304A Oxo-imidazolidine substituted cephalosporins and antibacterial
compositions and methods of combatting bacteria employing them
失效
氧代 - 咪唑烷取代的头孢菌素和抗菌组合物和使用它们的抗菌药物的方法
- 专利标题： Oxo-imidazolidine substituted cephalosporins and antibacterial compositions and methods of combatting bacteria employing them
- 专利标题（中）： 氧代 - 咪唑烷取代的头孢菌素和抗菌组合物和使用它们的抗菌药物的方法
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申请号： US590794申请日： 1975-06-27
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公开(公告)号： US4107304A公开(公告)日： 1978-08-15
- 发明人: Wilfried Schrock , Hans-Bodo Konig , Michael Preiss , Karl Georg Metzger , Michael Walkowiak
- 申请人： Wilfried Schrock , Hans-Bodo Konig , Michael Preiss , Karl Georg Metzger , Michael Walkowiak
- 申请人地址： DEX Leverkusen
- 专利权人： Bayer Aktiengesellschaft
- 当前专利权人： Bayer Aktiengesellschaft
- 当前专利权人地址： DEX Leverkusen
- 优先权： DEX2407715 19740218
- 主分类号： A61K31/545
- IPC分类号： A61K31/545 ; C07D501/20 ; C07D501/24 ; C07D501/34
摘要：
Cephalosporins of the formula ##STR1## their pharmaceutically-acceptable, nontoxic salts, and hydrates thereof are produced, whereinA is hydrogen; unsubstituted or substituted alkyl; aryl; or R.sub.1 --X--, whereinX is --CO-- or --SO.sub.2 --, andR.sub.1 is hydrogen, unsubstituted or substituted alkyl; aryl; thienyl; furyl; amino; alkylamino; dialkylamino; pyrrolidyl; or piperidyl;Or whenX is --CO--,R.sub.1 can also be alkoxy;B is phenyl, methylphenyl, chlorophenyl, hydroxyphenyl or the moiety ##STR2## E is hydrogen, hydroxyl or acetoxy; and C is a center of chirality.These compounds are particularly useful for their antimicrobial and, particularly, antibacterial effects.
公开/授权文献
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