发明授权
US4117148A 2,9-Dioxatricyclo [4,3,1,0,3,7] decane derivatives, processes for their
preparation and pharmaceutical compositions thereof
失效
2,9-二氧杂环己烷(4,3,1,0,3,7)+0癸烷衍生物,其制备方法及其药物组合物
- 专利标题: 2,9-Dioxatricyclo [4,3,1,0,3,7] decane derivatives, processes for their preparation and pharmaceutical compositions thereof
- 专利标题(中): 2,9-二氧杂环己烷(4,3,1,0,3,7)+0癸烷衍生物,其制备方法及其药物组合物
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申请号: US826681申请日: 1977-08-22
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公开(公告)号: US4117148A公开(公告)日: 1978-09-26
- 发明人: Peter Willibrord Thies , Samuel David
- 申请人: Peter Willibrord Thies , Samuel David
- 申请人地址: DE1 Hannover
- 专利权人: Kali-Chemie Pharma GmbH.
- 当前专利权人: Kali-Chemie Pharma GmbH.
- 当前专利权人地址: DE1 Hannover
- 优先权: DEX2730988 19770708
- 主分类号: C07D493/08
- IPC分类号: C07D493/08 ; A61K31/335
摘要:
3-AZIDOMETHYL-2,9-DIOXATRICYCLO[4,3,1,0.sup.3,7 ] DECANE DERIVATIVES ARE DISCLOSED WHICH EXHIBIT ANALGESIC, AS WELL AS ANTIPYRETIC AND ANTIPHLOGISTIC PROPERTIES, AND WHICH HAVE THE FORMULA (I) ##STR1## wherein: R.sub.1 represents alkyloxy or aralkyloxy;One of R.sub.2 and R.sub.3 is hydrogen and the other represents hydroxy, acyloxy or carbamyloxy, or R.sub.2 and R.sub.3 jointly represent oxygen; and,Y and y' each represent hydrogen or jointly form a bond,As well as pharmaceutical formulations thereof.By reducing the 3-azidomethyl compounds of formula (I), the corresponding 3-aminomethyl compounds are obtained which possess sedative properties and which are valuable intermediates for preparing 3-(mono- or dialkylaminomethyl)-2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decanes which exhibit sedative and soporific activities.
公开/授权文献
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