A toothbrush having a brushing unit and a dentifrice containing cartridge unit. The cartridge unit is shaped to permit it to be comfortably held in the hand and has a squeezable wall for the purpose of expelling dentifrice from the dentifrice-containing chamber therein. The dentifrice passage extending from the chamber to the brushing unit is normally closed by a valve which opens by the force of the dentifrice when the cartridge is squeezed. A check valve permits air to replace dentifrice that has been expelled from the cartridge chamber. The dentifrice may be introduced directly into the cartridge chamber, or it may be placed in a bag or tube and the dentifrice-containing bag or tube placed in the chamber. The bag or tube may have screw threaded or slip on type openings at one or both ends or one or both ends may be pierced by a needle or the like to allow the dentifrice to be squeezed out.